Antigenic Alteration on the Membrane of Cells from Animals Infected with Intracellular Parasites

概要

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Results of our macrophage migration inhibition test have confirmed that cells of animals infected with intracellular parasites acquire antigenic alteration as a result of having allowed the microbes to multiply in them. This finding would imply that, because of multiplication of a special species of microorganisms in the host's phagocytic cells, the antigenicity of the infected cells alters making them autoantigenic. Subsequent studies have demonstrated that the antigenic alteration on infected cells develops when primary culture cells as well as cells of established lines are infected in vitro either with intracellular parasites or with their microbial DNA. According to our hybridization tests and reassociation kinetic analyses, nucleotide sequence homology between the host's DNA and the DNA from bacteria which can grow intracellularly in the host was significantly greater than that between the DNA of bacteria growing only extracellularly and their host's DNA. These findings suggest the possibility that the antigenic alteration is an expression of genetic recombination between the genome brought in by the microbes and that of the host. We are inclined to think that the altered self antigen due to infections might play a vital role in the development of many biological phenomena.
北里大学の論文
1980-08-31