匂い受容体の機能解析を目指したバイオインフォマティクス(2003-2004年度神奈川大学共同研究奨励助成論文)

概要

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In order to delineate the functional aspects of odorant receptors as protein molecules, we here employed computational and biological approaches, each of which could eventually highlight different aspects of odorant receptors. We first characterized the non-redundant protein database to depict the general nature of proteins with a comprehensive database search strategy. We also employed a computational method called self-organizing map to understand possible relations of odorant receptors to other G-protein-coupled receptors. Furthermore, we have studied how to deliver foreign genes or proteins to olfactory sensory neurons in mice in vivo. Systematic synthesis of these computational and biological results could pave the way to our understanding of the whole nature of odorant receptors as protein molecules.
神奈川大学の論文
2005-05-25