代謝性アルカローシスの運動時における血中乳酸動態に及ぼす影響

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In order to determine the effect of acute induced matabolic alkalosis on the appearance of blood lactate during exercise, acid-base balance and blood lactate concentration (LA) at rest, during exercise and recovery after exhaustion were studied in seven long distance runners on two separate occasions after ingestion (0.3g・kg^<-1> body mass) of calcium carbonate (CaCO_3; placebo) and sodium bicarbonate (NaHCO_3; alkalosis). Mean values (±SD) in age, body mass and height of the subjects were 20.0±1.2 years, 56.6±5.4 kg, 169.7±4.3 cm, respectively. A 1-min incremental exercise test was performed on a Monark cycle ergometer in the two treatments. Blood pH, bicarbonate (HCO^-_3) and LA levels at rest in alkalosis increased significantly compared to placebo (p<0.05). Similar LA level was found at work rates below the anaerobic threshold in the two treatments, but there was a significant difference between placebo (9.12±2.05mmol・1^<-1>) and alkalosis (11.97±1.93mmol・1^<-1>) at exhaustion. In addition, LA during recovery period was maintained higher level in alkalosis compared to placebo. However, the absolute amount of change in LA from exhaustion to 3 min recovery after exhaustion showed a tendency to be greater in placebo (3.07±1.82mmol・1^<-1>) than in alkalosis (2.43±0.87mmol・1^<-1>). Consequently, these results would seem to reflect that lactate release from skeletal muscle is increased by high extracellular HCO^-_3 level. It is concluded that the improvement of exercise performance previously reported for alkalosis condition may be due to high lactate release from skeletal muscle to blood and/or less accumulation in the intracellular H^+.
鹿児島国際大学の論文
1992-01-15

代謝性アルカローシスの運動時における血中乳酸動態に及ぼす影響

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