アルドステロン分泌に及ぼす血液pHの影響について

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The present investigation was carried out to elucidate whether changes in blood pH induced by administrations of alkalinizing or acidifing agents influence aldosterone secretion. Since aldosterone secretion is known to be regulated by various factors such as the renin-angiotensin system, adrenocorticotropin (ACTH) and serum potassium level, these indices were simultaneously measured during manipulation. Oral administration of NaHCO_3 (alkalinization) of 0.3g・body weight^<-1> resulted in a fall of serum aldosterone with an increase in blood pH, whereas serum cortisol and plasma renin activity remained unchanged. NH_4Cl ingestion (acidification) caused an elevation of aldosterone though the increase was not significant statistically, whereas CaCO_3 ingestion (control) resulted in a significant fall in serum aldosterone. In the experiment of NH_4Cl ingestion, both serum cortisol and plasma renin activity decreased significantly. These results suggest that the fall of aldosterone by alkalinization and the rise of aldosterone by acidification are not induced by either renin angiotensin system or ACTH. On the other hand, serum potassium level fell or rose during alkalinization or acidification. The pattern of the change was similar to the change in proton concentration. From these results, it is concluded that changes in blood pH seem to influence aldosterone secretion independent of renin angiotensin system and ACTH, however, possible involvement of serum potassium concentration on aldosterone secretion can not be denied.
中京大学の論文
1996-03-19

アルドステロン分泌に及ぼす血液pHの影響について

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