低酸素環境の運動時エネルギー代謝への影響 (続報) : 血漿乳酸と血液アンモニア濃度の変化

概要

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Since decreased oxygen transport during exercise may enhance the anaerobic metabolism, we studied the effect of hypoxia on anaerobic glycolysis and adenylate kinase reaction. Six young non-acclimatized male subjects were employed. Each subject carried out 3 exercise tests (Hypo, Max and Sub) on a bicycle ergometer. In Max or Hypo, an incremental exercise until exhaustion was performed under air or 12% oxygen gas. In Sub, work load was the same as Hypo but under air. The work load of Hypo and Sub was two thirds of that of Max. Plasma lactate rose after exercise and fell thereafter similarly in both Max and Hypo without significant differences at any points. Its changes in Sub were far less than the other 2. Blood ammonia rose with exercise in all 3 experiments, but the increases differed among experiments; they were largest in Max and smallest in Sub. The increases from pre-exercise levels in Max and Sub were 159% and 63% of Hypo, respectively. The results suggest that (1) the shift of energy metabolism to anaerobic glycolysis takes place more easily than to adenylate kinase process under hypoxia; and (2) while reliance of the energy metabolism on anaerobic glycolysis is mostly determined by relative intensity of exercise, the reliance on the adenylate kinase process is determined not only by relative intensity but also absolute intensity of exercise.
中京大学の論文
1998-11-01