Possible Roles of Schwann Cells in Peripheral Nerve Degeneration and Regeneration

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To ascertain the possible roles of Schwann cells in nerve regeneration, morphological changes of these cells at the proximal stump of the transected mouse sciatic nerve was examined. One or 2 days after transection, an extensive degradation of myelin sheath occurred near the cut end of the proximal stump. Schwann cells in this region contained variously-sized myelin balls in the cytoplasm. Three to five days after transection, Schwann cells in the proximal stump exhibited several sections of rough-surfaced endoplasmic reticulum and welldeveloped Golgi complexes in an abundant cytoplasm. Mitotic figures were often observed in these cells. In the mini-neuromas formed at the distal tip of the proximal stump, Schwann cells extended thin cytoplasmic processes along the regenerating growth cones and axonal shafts. Seven or ten days after transection, each Scwann cell encircled 1 or 2 thick axons with their thin cytoplasmic processes, and remyelination occurred in these axons. However, thin axons remained free from these processes, and some exhibited degenerative changes. After 14 and 21 days, regenerating axons gradually decreased in number, and each thick axon was encircled by its own myelin sheath of several layers. These findings suggest that Schwann cells at the proximal stump might be involved in several important events for nerve regeneration such as demyelination, trophic support, control of the extension and maturation of regenerating axons.
神戸大学の論文
1997-12-26

Possible Roles of Schwann Cells in Peripheral Nerve Degeneration and Regeneration

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