Influence of Electrical Stimulation on Nerve Regeneration in the Transected Mouse Sciatic Nerve
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概要
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Influence of the electrical stimulation on nerve regeneration was electron micro-scopically examined in the transected mouse sciatic nerve. To know the influence on the repairing and early regenerating processes, the electrical stimulation was applied to the proximal stump soon after the transection. At 6 hours after the stimulation, a number of small vesicles accumulated in several myelinated axons at their cut end (terminal vesicle accumulation), and regenerating axonal sprouts formed at some nodes of Ranvier locating near the cut end. These morphological changes were almost the same as in the proximal stump which did not receive the stimulation. These findings suggested that the electrical stimulation might not severely suppress the repairing or early regenerating processes. To know the influence on the regenerating axons, the electrical stimulation was applied at 48 hours after the transection. At 6 hours after the stimulation, some growth cones exhibited the degenerative changes, such as swelling of mitochondria, rupture of the small vesicles, but the regenerating axonal shafts appeared to be almost normal. At 24 hours after the stimulation, morphological appearance of the growth cones and axonal shafts was almost the same as seen in the control study. These findings suggest that the growth cones might be more sensitive to the electrical stimulation than the axonal shafts, but the influence of the stimulation on regenerating axons might be transient, and they might be able to recover soon.
- 神戸大学の論文
- 1999-12-26
著者
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Matsubara Takako
Faculty of Health Science, Kobe Uni-versity School of Medicine
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Matsumoto Tomoko
Department Of Rehabilitation Osaka City General Hospital
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Matsumoto Tomoko
Department Of Orthopaedic Surgery Nagasaki University School Of Medicine
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Miki Akinori
Faculty Of Health Science Kobe Uni-versity School Of Medicine
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Matsubara Takako
Faculty Of Health Science Kobe Uni-versity School Of Medicine
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Kohbu Yoshihide
Faculty of Health Science, Nagoya University School of Medicine
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Kohbu Yoshihide
Faculty Of Health Science Nagoya University School Of Medicine
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Matsumoto Tomoko
Department of Medicine, Kidney Center, Tokyo Women's Medical College
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Miki Akinori
Faculty of Health Science, Kobe Uni-versity School of Medicine
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