Monoclonal antibodies Analysis of S-100 Protein Expression in the Developing Human Retina
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概要
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We investigated the localization and development of S-100 protein immunoreactivity in the developing human retina ranging in age from 13 gestational weeks (GW) to adulthood by using anti-S-100 protein monoclonal antibodies (α and β chains). Numerous astrocytes and ganglion cells of the inner retinal layers were positively stained with these antibodies. The first S-100 protein-positive cells were observed in the region near the optic disc at 24 GW and with increasing age this reactivity extended anteriorly towards the ora serrata. No immunoreactivity was found either in the Muller's cells or in the perivascular glial cells of the retina. The results of this study indicate that S-100 protein immunoreactive astrocytes and ganglion cells first appear at the posterior pole of the retina and gradually spreading towards the ora serrate.
- 神戸大学の論文
- 1997-01-24
著者
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Itoh Hiroshi
First Pathology Faculty Of Medical Sciences University Of Fukui
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Miki Akinori
Faculty of Health Sciences, Kobe University School of Medicine
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Itoh Hiroshi
First Department Of Pathology Kobe University School Of Medicine
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Miki Akinori
Faculty Of Health Science Kobe Uni-versity School Of Medicine
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