Expression of S-100 Protein and Neuron-Specific Enolase in the Developing and Adult Human Retina : An Immunohistochemical Study on 24 Cases

概要

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Immunohistochemically, we examined the developmental expression of S-100 protein and neuron-specific enolase (NSE) in the human retina. The expression of S-100 protein examined with polyclonal antiserum against S-100 protein was almost the same as that examined with monoclonal antibodies in a previous study. The result of the present and the previous studies confirmed that S-100 protein is expressed preferentially in the ganglion cells and astrocytes, but not in the Muller cells, and suggest that the expression of this protein might be closely related to the differentiation and/or maturation of these cells. On the other hand, NSE began to be expressed in the human retina slightly earlier than S-100 protein, and not only in the ganglion cells but also in the cells of the outer and inner neuroblastic layers. At later developmental stages, NSE was strongly expressed in the inner plexiform layer. NSE was not expressed in astrocytes or Muller cells at any stages examined in the present study. These findings suggest that NSE could be used as a reliable maker for the neuronal elements in the human retina, and that the strong expression of NSE in the inner plexiform layer might be closely related to the synaptogenesis and/or synaptic functions in the related regions.
神戸大学の論文
1997-01-24