ストレスファイバの力学特性に基づいた接着細胞の力学構造モデル(S02-3 生体組織のマルチスコープメカニクス(3).細部のマルチモーダル・メカニクス,S02 生体組織のマルチスコープメカニクス)

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In this paper, mechanical architecture of adherent cells such as endothelial cells was discussed based on experimental evaluation of mechanical properties of subcellular structural components. Tensile properties of single stress fibers, bundles of actin filaments, in endothelial cells were obtained with in vitro micromanipulation. Preexisting tension in the stress fibers was then evaluated from the tensile properties and preexisting strain. Physiological tension level of the stress fibers was found to be 1-10 nN order of magnitude, which was "comparable to that of the traction force applied by adherent cells at their focal adhesion sites. Electron micrograph showed a possibility of the nucleus and membrane-bound organelles in endothelial cells as an intracellular compressive stress-bearing element. These results proposed that force balance between the organelles would be a major determinant of cellular morphology and force transmission in the cytoplasm.
一般社団法人日本機械学会の論文
2004-09-04