T0201-3-4 アクチンストレスファイバのねじり収縮([T0201-3]細胞の構造と流れにおけるマイクロ・ナノスケール解析(3))

概要

論文の詳細を見る
Nonmuscle actomyosin or actin stress fibers play an essential role in cellular adaptation to physical environment, yet the relation between their function and structure remains poorly understood. Herein, we provide the first evidence that stress fibers twist during contraction or stretching. We directly pulled or induced MgATP-based contraction of stress fibers isolated from the substrate. Twisting motion was observed in both cases, suggesting that stress fibers have a helical structure. Given that stress fibers are dynamic organelles that bear tensile stress in appropriate places inside cells, the helical structure seems to be advantageous as it is easy to disintegrate when compressive force is applied, serving as a ready source of actomyosin to reassemble new stress fibers.
2010-09-04