T0201-1-7 再生系細胞に存在する張力ホメオスタシスの幾つかの証拠([T0201-1]細胞の構造と流れにおけるマイクロ・ナノスケール解析(1))

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In previous work, we proposed based on our measurements that nonmuscle actomyosin acts as a "mechanocontroller" in proliferative cells that allows a transient cellular response to mechanical perturbations from the set-point determined by the phosphorylation level of myosin light chain. Loss of this system results in a dysfunctional state characterized by sustained pro-inflammatory pathways. Thus, a model that only considers biochemical signaling pathways in tension regulation without also considering the autonomous biophysical contributions of actomyosin, mechanocontroller, fails to explain the transient response needed for cellular adaptation. Our study provides a molecular basis for the contribution of nonmuscle actomyosin contractility to cellular adaptation toward the physical environment that regulates cell function in physiology and disease.
2010-09-04