F-0912 ラット胸大動脈平滑筋細胞の形態ならびに収縮特性の高血圧に対する応答(J21-3 細胞のバイオメカニクス)(J21 生体構造と組織のバイオメカニクス)

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The effects of hypertension on dimensions and contractile response of the aortic smooth muscle cells (SMCs) were studied in male Wistar rats. SMCs were isolated from aortic tissue by enzymatic digestion. The change of the cell shape due to the contraction induced with 10μM of norepinephrine (NE) was observed in an aerated Krebs-Henseleit solution at 37℃ with a microscope. The cell diameter before contraction was significantly larger in hypertensive aorta than in the controls, while the length was not statistically different. The cell shortening induced with NE was significantly smaller (P<0.01) in the hypertensive aortas than in the controls. Reduction of the contractility in the hypertensive aortas has been observed in the experiments with whole vessel segment. Hypertension causes smooth muscle hypertrophy. Hypertrophy may stimulate biosyntnetic response in the cell and thus may inhibit contractile response.
一般社団法人日本機械学会の論文
2001-08-22