G0200-3-5 大動脈瘤壁の破裂リスク予測を目指した破裂時力学特性の計測(バイオエンジニアリング部門一般講演(3),社会変革を技術で廻す機械工学)

概要

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Mechanical properties of the thoracic aortic aneurysm (TAA) tissues were measured in a pressure-imposed test along with histological analysis to estimate their rupture risk. Quadrilateral specimens obtained from TAA were sandwiched with plates having a hole and pressurized from one side of the hole to bulge into the other side until rupture. Intramural stress and strain of each specimen were calculated from its deformation-loading pressure relationship to obtain its ultimate strength and tangent modulus. Histological analysis was then performed to obtain the area fraction of histological components. The maximum of the tangent modulus during pressurization had a significant correlation with both area fraction of collagen and ultimate strength, indicating that tangent modulus can be used as an index of rupture risk. While tangent modulus continuously increased with intramural stress until rupture for normal porcine thoracic aorta, it tended to reach a plateau for TAA. Stress-tangent modulus relation may also reflect the rupture risk.
2010-09-04