The effects of occlusal hypofunction and its recovery on the periodontal tissues of the rat molar : ED1 immunohistochemical study
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概要
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The aim of this study was to clarify the relationship between occlusal function and the periodontal tissue remodeling by assessing the distribution of ED1-immunopositive cells in the periodontal tissues incident to experimentally induced occlusal hypofunction and its recovery. Rats were divided into untreated normal and two experimental groups, hypofunction and recovery. In the experimental groups, an anterior bite plate and a metal cap were attached to the maxillary and mandibular incisors, respectively, in order to produce hypofunction at molar region. In the hypofunction group, the animals were sacrificed at 1, 3, 7 and 14 days post-attachment of the appliances. In the recovery group, the appliances were removed at 7 days post-attachment and the rats were sacrificed at 1, 3 and 7 days post-removal. Frozen cross sections of the decalcified mandibular first molars were stained with ED1 monoclonal antibody that recognizes exclusively cells of the mononuclear phagocyte lineage. Under occlusal hypofunction, the number of ED 1-immuno-positive cells in the periodontal ligament (PDL) progressively decreased and the alveolar bone showed a smooth surface. After recovery of occlusal function, the ED 1-positive cells immediately increased mainly inside the alveolar bone, which displayed a rugged profile with active bone resorption. These results suggest that some ED1-positive cells, presumably osteoclastic lineage cells, play an important role on the periodontal tissue remodeling in response to occlusal stimuli.
- 日本矯正歯科学会の論文
著者
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SOMA Kunimichi
Orthodontic Science, Department of Orofacial Development and Function, Division of Oral Health Scien
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IIDA Junichiro
Department of Oral Functional Science (Section of Orthodontics), Graduate School of Dental Medicine,
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Iida Junichiro
Department Of Oral Functional Science Graduate School Of Dental Medicine Hokkaido University
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Iida Junichiro
Department Of Oral Functional Science (section Of Orthodontics) Graduate School Of Dental Medicine H
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Iida Junichiro
First Department Of Orthopedics Faculty Of Dentistry Tokyo Medical And Dental University
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Iida J
Department Of Oral Functional Science Graduate School Of Dental Medicine Hokkaido University
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EUI-SEOK Suhr
Orthodontic Science, Department of Orofacial Development and Function, Division of Oral Health Scien
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WARITA Hiroyuki
Orthodontic Science, Department of Orofacial Development and Function, Division of Oral Health Scien
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Eui-seok Suhr
Orthodontic Science Department Of Orofacial Development And Function Division Of Oral Health Science
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Soma K
Orthodontic Science Department Of Orofacial Development And Function Division Of Oral Health Science
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Soma Kunimichi
Orthodontic Science
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Warita H
Orthodontic Science Graduate School Tokyo Medical And Dental University
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Warita Hiroyuki
Orthodontic Science
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Soma K
Orthodontic Science Department Of Orofacial Development And Function Division Of Oral Health Science
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Warita Hiroyuki
Tokyo Medical And Dental Univ.
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