スキャンドネストの局所麻酔効果に関する基礎的検討 : イキシロカインおよびシタネスト-オクタプレシンとの比較

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Effects of Scandonest[○!R] (mepivacaine hydrochloride) were investigated in comparison to Xylocaine[○!R] (lidocaine hydrochloride with epinephrine) and Citanest[○!R]-Octapressin[○!R] (propitocaine hydrochloride with felypressin). Intracutaneous injection of Scandonest[○!R] inhibited twitch contraction induced by pin-prick stimulation of guinea-pig dorsal skin. Although the duration of anesthetic effects of Sandonest[○!R] was shorter than those of Xylocaine[○!R] and Citanest[○!R] -Octapressin[○!R], Scandonest[○!R] had a longer effect than 3% lidocaine and 3% propitocaine without vasoconstrictors. Surface anesthesia evaluated by corneal reflex also showed that Scandonest[○!R] had the longest anesthetic action. Scandonest[○!R] inhibited compound action potentials and conduction velocity in the frog sciatic nerve. When the time to inhibit the peak amplitude of the action potential by half (t_<1/2>) inhibition) and the time to restore the peak amplitude to half (t_<1/2> recovery) were measured, the peak for A^α fibers were slowly inhibited and quickly recovered in comparison to other peaks (Aβ, Aγ and Aδ fibers). There was no significant difference on these effects between Scandonest[○!R], Xylocaine[○!R] and Citanest[○!R] -Octapressin[○!R]. Our results indicated that the relatively longer anesthetic action observed after intracutaneous injection of Xylocaine[○!R] and Citanest[○!R] -Octapressin[○!R] is probably caused by the addition of vasoconstricting agents. Furthermore, unexpected allergic responses might partly contribute to the prolonged analgesic action observed in intracutaneous injection of Citanest[○!R] -Octapressin[○!R]. As blood vessels are densely distributed in oral area, Scandonest[○!R] might have a shorter action than Xylocaine[○!R] or Citanest[○!R] -Octapressin[○!R] in oral injection. To avoid side effects caused by vasoconstricting and antiseptic agents (epinephrine and methylparaben [4-hydroxy benzoic acid methylester]) , Scandonest[○!R] is a useful drug for elderly patients especially those with heart disease, hypertension, diabetes mellitus etc.
福岡歯科大学学会の論文
1996-06-30

スキャンドネストの局所麻酔効果に関する基礎的検討 : イキシロカインおよびシタネスト-オクタプレシンとの比較

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