リグノスパン【○!R】カートリッジの局所麻酔作用と急性毒性について

概要

論文の詳細を見る
The anesthetic action and acute toxicity of 2% Lignospan【○!R】 were examined in comparison with 2% Xylocaine【○!R】. The surface anesthetic action observed by the corneal reflex in guinea pigs was appeared immediately after applications of the two local anesthetics and continued for about 12min. In infiltration anesthesia, Lignospan【○!R】 depressed the twitching response of intracutaneous wheels in guinea pigs for 120min to the same degree as Xylocaine【○!R】. The onset time taken for the development of plexus anesthesia in frogs by Lignospan【○!R】 and by Xylocaine【○!R】 was 6.88±1.13min and 6.75±1.28min, respectively. The time until the compound action potential of the isolated motor nerve (A α neuron) of frogs was depressed to half by Lignospan【○!R】 was 14.29±2.29min and 14.71±3.15min by Xylocaine【○!R】. The LD_<50> value of Lignospan【○!R】 was 261 (95% C.L : 242-282) mg/ kg and that of Xylocaine【○!R】 was 287 (95% C.L : 268-307) mg/kg. These results suggest that the potency of Lignospan【○!R】 in local anesthesia and toxicity is almost equal to that of Xylocaine【○!R】.
福岡歯科大学学会の論文
1995-12-31