歯の細胞外マトリックスと石灰化(<特集>歯科における結合組織研究の進歩)

概要

論文の詳細を見る
Uncalcified tooth enamel is composed of matrix proteins. The proteins are degraded and deleted just before the calcification. Fully calcified enamel contains almost no proteins. The major component of the uncalcified enamel matrix is amelogenin, Which is rich in Pro and is hydrophobic. This protein forms aggregates and reserves spaces for future calcification. Specific proteases degrade this protein before the calcification. Tooth dentin contains collagenous matrix. Mineral crystals deposit in and around the collagen fibrils during the calcification. Dentin matrix contains minor proteins called non-collagenous proteins. One of them is phosphophoryn, a unique phosphoprotein of dentin. This protein is a highly acidic protein which is rich in P-Ser and Asp. It is immobilized on collagen matrix and induces nucleation of mineral crystals. Investigators think that phosphophoryn is involved in calcification of dentin.
日本結合組織学会の論文
2000-03-25