<原著>歯肉溝滲出液による成人性歯周炎の病勢診断

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The purpose of this study was to evalute the pathological changes of the penodontal disease by measurement of total protein, matrix metalloproteinase (MMP)-8, interleukm (IL)-1 β and granulocyte macrophage colony-stimulating factor (GM-CSF) in the gingival crevicular fluid (GCF). A total of 157 sites were used in the experiment (124 sites with adult penodontitis and 33 sites with healthy penodontal tissue). The measurement of total protein in GCF was performed by Bradford method. The determination of MMP-8 in GCF was performed by the EIA system. The measurements of IL-1 β and GM-CSF were used by the ELISA systems. The flow of GCF, gingival index (GI), gingival bleeding index (GBI) and probing depth were examined as clinical parameters. The compositions of amino acid in GCF were analyzed by the ammo acid analysis. The results were as follows 1 There were close correlations among the inflammation indices (flow of GCF, GI and GBI) and the amounts of total protein, IL-1 β and MMP-8 in GCF. 2 The content of GM-CSF in GCF was not detected by this ELISA system (<7 6pg). 3 By the ammo acid analysis of GCF, the content of hydroxyprolm was less than the experimental error (0 001<residue/1000residues). 4 The rose-diagram of ammo acids in GCF characterised the status of the penodontal diseese. Thease results suggested that the measurements of total protein, IL-1 β and MMP-8 in GCF were useful for the diagnosis of the penodontal disease activity and the ammo acids analysis of GCF might characterize the pathological changes of the periodontal disease.
北海道医療大学の論文
1996-12-31

<原著>歯肉溝滲出液による成人性歯周炎の病勢診断

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