重窒素二酸化窒素の生体内動的観察

概要

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The dynamic pathway of inhaled nitrogen dioxide was investigated in rats exposed to ^<15>NO_2 for the specified experimental period. After exposure, various organs, blood and urine were taken out, dried by lyophilization, and then digested by the semi-micro Kjeldahl method. Determination of ^<15>N was performed by mass-spectrometry. The ^<15>N content (atom % excess) of each sample was calculated by subtracting the natural ^<15>N content which was separately estimated from normal rats. The ^<15>N content was relatively high in urine, plasma and kidneys, and low in liver, trachea, heart and brain. It was concluded that the inhaled nitrogen dioxide was quickly absorbed into blood and was excreted into urine. Nitrite was detected in the plasma obtained from the rats exposed to ^<15>NO_2 at levels higher than 10 ppm, and a significant correlation was found between the concentration of nitrite and the exposure concentration of ^<15>NO_2.
社団法人日本産業衛生学会の論文
1982-07-20