LYMPHOTROPIC DELIVERY OF CYCLOSPORIN A BY INTRAMUSCULAR INJECTION OF BIODEGRADABLE MICROSPHERES IN MICE
スポンサーリンク
概要
- 論文の詳細を見る
Biodegradable microspheres containing cyclosporin A (CsA), an immunosuppressant, enabled the lymphotropic delivery of the durg over the log term by parenteral administration in mice. The CsA encapsulated in the microspheres of polylactic acid polymer (Mw, 9000) was released over 30 days in vitro. The intramuscular injection of the microspheres containing CsA in the femoral site of mice maintained the drug at a high level in the inguinal lymph nodes over 1 month, although only low blood levels of the drug were observed.
- 公益社団法人日本薬学会の論文
- 1996-11-15
著者
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Yoshikawa Hiroshi
Department Of Biopharmaceutics Kyoto Pharmaceutical University:exploratory Development Laboratories
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SEEBACH Stephen
Max-Planck-Institut fur Experimentelle Medizin
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Yoshikawa Hiroshi
Department Of Drug Dosage Form Design Faculty Of Pharmaceutical Sciences Toyama Medical & Pharma
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Yoshikawa Hiroshi
Department of Applied Physics, Handai Frontier Research Center, and Venture Business Laboratory of Center for Advanced Science and Innovation, Osaka University, Suita, Osaka 565-0871, Japan
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