Heterocycles. VIII. Syntheses of 12-Acetoxybenzo [c] phenanthridines
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概要
- 論文の詳細を見る
The compound obtained from the phenacylimide (5) by treatment with p-toluenesulfonic acid and ethylene glycol in benzene is the furoisocarbostyril (7), in contrast to a previous report. Reduction of 5 with sodium borohydride followed by treatment with hydrochloric acid and then hydrogen chloride affords the styrylisocarbostyril (10), photolysis of which provides the benzo [c] phenanthridines (11) and (12), and the amides (13) and (14). The ethylenedioxyimide (8) obtained from 5 affords the styrylisocarbostyrils (18) and (19) by a similar procedure together with enol acetylation. Photolysis of a mixture of 18 and 19 provides the 12-acetoxybenzo [c] phenanthridines (20) and (21).
- 公益社団法人日本薬学会の論文
- 1980-07-25
著者
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恩田 政行
School of Pharmaceutical Sciences, Kitasato University
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山口 裕子
Research Laboratories Yoshitomi Pharmaceutical Industries Ltd.
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恩田 政行
Shenyang Pharmaceutical University
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針谷 義弘
北里大薬
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山口 裕子
School of Pharmaceutical Sciences, Kitasato University
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針谷 義弘
School of Pharmaceutical Sciences, Kitasato University
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高松 生子
School of Pharmaceutical Sciences, Kitasato University
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草野 俊郎
School of Pharmaceutical Sciences, Kitasato University
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高松 生子
School Of Pharmaceutical Sciences Kitasato University
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草野 俊郎
School Of Pharmaceutical Sciences Kitasato University
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