Heterocycles. XIII. Syntheses and Absolute Configurations of Chiral Benzo [c] phenanthridines
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概要
- 論文の詳細を見る
Chiral benzo [c] phenanthridines have been synthesized. Aminolysis of the (-)-epoxyhydroxy lactone (3) with methylamine stereospecifically gives the (+)-trihydroxy lactam (5), from which the (+)-10b-hydroxychelidonine (7) and (+)-11-epichelidonine analogs (10) are derived. The absolute configurations of the compounds obtained are assigned on the basis of that of (-)-3 and the results obtained from the subsequent stereocontrolled reactions. The absolute configurations of (+)-7 and (+)-10 are confirmed by Horeau's method.
- 公益社団法人日本薬学会の論文
- 1982-04-25
著者
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恩田 政行
School of Pharmaceutical Sciences, Kitasato University
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山口 裕子
Research Laboratories Yoshitomi Pharmaceutical Industries Ltd.
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恩田 政行
Shenyang Pharmaceutical University
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針谷 義弘
北里大薬
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山口 裕子
School of Pharmaceutical Sciences, Kitasato University
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針谷 義弘
School of Pharmaceutical Sciences, Kitasato University
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高松 生子
School of Pharmaceutical Sciences, Kitasato University
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高松 生子
School Of Pharmaceutical Sciences Kitasato University
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