Heterocycles. VI. An Approach to Corynoline Analogues
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概要
- 論文の詳細を見る
The 2-methyl ketone (2a, b), which are derived from the ketones (1a, b), afford the cis-imines (7a, b) and trans-imines (8a, b) by the Leuckart and Bischler-Napieralski reactions. Their methiodies (9a, b and 10b) are converted into the cis-lactams (15a, b) and trans-lactam (17b) via oxidation of the pseudo cyanides (14a, b and 16b). Bromination and successive dehydrobromination of 2a give the enone (20) which affords the cis-imine (23) and trans-imine (24) by the same procedure as above. The cis-methiodide (25) of 23 is reduced to give the cis-amine (26). The cis-lactams (15a, b) and cis-amine (26) can be connected with the synthetic methods of corynoline analogues, which were already known.
- 公益社団法人日本薬学会の論文
- 1978-11-25
著者
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恩田 政行
School of Pharmaceutical Sciences, Kitasato University
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恩田 政行
Shenyang Pharmaceutical University
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針谷 義弘
北里大薬
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針谷 義弘
School of Pharmaceutical Sciences, Kitasato University
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堀江 鈍也
School of Pharmaceutical Sciences, Kitasato University
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堀江 鈍也
School Of Pharmaceutical Sciences Kitasato University
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