Utilization of Protopine and Related Alkaloids. XII. An Improved Route to an Analog of the Alkaloid Corynoline
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概要
- 論文の詳細を見る
Photolysis of dihydroisoquinoline (2) in the presence of nitrosobenzene gives the epoxyimine (10), sodium borohydride reduction of which affords the aniline (14). Reaction of the dehydro compound (17) derived from 14 with performic acid followed by hydrolysis provides the diol (20). Hydrogenolysis of 20 over a palladium catalyst affords the corynoline analog (7). All compounds are formed under strictly stereoselective control.
- 公益社団法人日本薬学会の論文
- 1980-03-25
著者
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恩田 政行
School of Pharmaceutical Sciences, Kitasato University
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山口 裕子
Research Laboratories Yoshitomi Pharmaceutical Industries Ltd.
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恩田 政行
Shenyang Pharmaceutical University
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針谷 義弘
北里大薬
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山口 裕子
School of Pharmaceutical Sciences, Kitasato University
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針谷 義弘
School of Pharmaceutical Sciences, Kitasato University
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