SYNTHESIS OF 2-ARYL-5,6-DIHYDRO-(1)BENZOTHIEPINO[5,4-C]PYRIDAZIN-3(2H)-ONE BY A NOVEL DEHYDROGENATION REACTION
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概要
- 論文の詳細を見る
Treatment of 2-(4-methoxyphenyl)-4,4a, 5,6-tetrahydro-(1)benzothiepino[5,4-c]pyridazin-3(2H)-one 7-oxide (1a) in methanesulfonic acid (MSA) gave 2-(4-methoxyphenyl)-5,6-dihydro-(1)benzothiepino[5,4-c]pyridazin-3(2H)-one (2a) in 80% yield. Compound 2a was also obtained by reating 4a, a deoxidized compound of 1a, with dimethylsulfoxide (DMSO) in MSA, trifluoroacetic acid or HBr-AcOH. Apparently this novel dehydrogenation reaction was derived from an acid catalyzed intermolecular redox reaction, that is, a concerted elimination of 4-hydrogen, 4a-hydrogen on 1a or 4a and sulfinyl oxygen on 1a or DMSO.
- 公益社団法人日本薬学会の論文
- 1991-02-25
著者
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山口 裕子
Research Laboratories Yoshitomi Pharmaceutical Industries Ltd.
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小畑 実
Research Laboratories Yoshitomi Pharmaceutical Industries Ltd.
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中尾 達
Research Laboratories, Yoshitomi Pharmaceutical Industries, Ltd.,
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中尾 達
Central Research Laboratories, Yoshitomi Pharmaceutical Industries, Ltd.,
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小畑 実
Central Research Laboratories, Yoshitomi Pharmaceutical Industries, Ltd.,
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山口 裕子
Central Research Laboratories, Yoshitomi Pharmaceutical Industries, Ltd.,
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田原 哲治
Central Research Laboratories, Yoshitomi Pharmaceutical Industries, Ltd.,
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田原 哲治
Research Laboratories Yoshitomi Pharmaceutical Industries Ltd.
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中尾 達
Research Laboratories Yoshitomi Pharmaceutical Industries Ltd.
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