STEREOSELECTIVE OXIDATION OF 2-(4-CHILOROPHENYL)-4a, 5-DIHYDRO-2H-(1)BENZOTHIOPYRANO[4,3-c]PYRIDAZIN-3(4H)-ONE TO SULFOXIDE
スポンサーリンク
概要
- 論文の詳細を見る
Stereoselective oxidation of 2-(4-chlorophenyl)-4a, 5-dihydro-2H-(1)benzothiopyrano[4,3-c]pyridazin-3(4H)-one (1) to sulfoxides with a variety of oxidants was examined under mild conditions. The oxidation with Pb(OAc)_4 and NaBrO_2 stereoselectively gave the trans-sulfoxide (2) in good yield. The peroxy reagents and NaIO_4 afforded mostly the cis-isomer (3).
- 公益社団法人日本薬学会の論文
- 1990-11-25
著者
-
丸林 信洋
Research Laboratories, Yoshitomi Pharmaceutical Industries, Ltd.,
-
田原 哲治
Research Laboratories, Yoshitomi Pharmaceutical Industries Ltd.,
-
小畑 実
Research Laboratories Yoshitomi Pharmaceutical Industries Ltd.
-
中尾 達
Research Laboratories, Yoshitomi Pharmaceutical Industries, Ltd.,
-
田原 哲治
Research Laboratories Yoshitomi Pharmaceutical Industries Ltd.
-
中尾 達
Research Laboratories Yoshitomi Pharmaceutical Industries Ltd.
-
森田 憲司
Research Laboratories Yoshitomi Pharmaceutical Industries Ltd.
-
川上 実
Research Laboratories, Yoshitomi Pharmaceutical Industries, Ltd.,
-
丸林 信洋
Research Laboratories Yoshitomi Pharmaceutical Industries Ltd.
-
川上 実
Research Laboratories Yoshitomi Pharmaceutical Industries Ltd.
関連論文
- Atropisomerism in 4-(2-Thienyl)-4H-1,2,4-triazole Derivatives
- Comparative Pharmacokinetics of Sulpiride and N-[(1-Butyl-2-pyrrolidinyl)methyl]-2-methyl-5-sulfamoyl-2,3-dihydrobenzofuran-7-carboxamide Hydrochloride, a New Lipophilic Substituted Benzamide in Rats
- PAF ANTAGONISTIC ACTIVITY OF SOME THIENO[3,2-f][1,2,4]TRIAZOLO[4,3-a][1,4]DIAZEPINES(Communication to the Editor)
- Physagulin C, a New Withanolide from Physalis angulata L.
- TWO NEW ERGOSTANE DERIVATIVES FROM TUBOCAPSICUM ANOMALUM(SOLANA CEAE)
- Potential Neuroleptic Agents, N-[(2-Pyrrolidinyl)methyl]-2,3-dihydrobenzofuran-7-carboxamide Derivatives
- Synthesis and Biological Activities of Optical Isomers of 2-(4-Chlorophenyl)-5,6-dihydro-(1)benzothiepino[5,4-c]pyridazin-3(2H)-one 7-Oxide
- SYNTHESIS OF 2-ARYL-5,6-DIHYDRO-(1)BENZOTHIEPINO[5,4-C]PYRIDAZIN-3(2H)-ONE BY A NOVEL DEHYDROGENATION REACTION
- Parsonsianine, a Macrocyclic Pyrrolizidine Alkaloid from the Leaves of Parsonsia laevigata (Studies on Parsonsia, III)
- CHARACTERIZATION OF A MINOR COMPOUND, WHICH ACCOMPANIES THE USUAL 22α (R)-0,25β (S)-SPIROSTANOL GLYCOSIDE, AS A NOVEL TYPE OF 22β (S)-0,25α (S) ANALOG
- Synthesis and Pharmacology of 3,4-Dihydro-3-oxo-1,4-benzoxazine-8-carboxamide Derivatives, a New Class of Potent Serotonin-3 (5-HT_3) Receptor Antagonists
- Syntheses and Biological Activities of Optical Isomers of 3-Chloro-5-[3-(2-oxo-1,2,3,5,6,7,8,8a-octahydroimidazo[1,2-a]pyridine-3-spiro-4'-piperidino)propyl]-10,11-dihydro-5H-dibenz[b, f]azepine (Mosapramine) Dihydrochloride
- Studies of the Synthesis of Condensed Pyridazine Derivatives. IV. Synthesis and Anxiolytic Activity of 2-Aryl-5,6-dihydro-(1)benzothiepino[5,4-c]pyridazin-3(2H)-ones and Related Compound
- 縮合Pyridazine誘導体の合成研究(第3報)縮合Triazolopyridazine誘導体の合成とBenzodiazepine受容体親和性
- 縮合Pyridazine誘導体の合成研究(第2報)2-Aryl-4,4a, 5,6-tetrahydropyridazino-[4,3-c]quinolin-3(2H)-one, 2-Aryl-4a, 5-dihydro-2H-(1)benzothiopyrano[4,3-c]-pyridazin-3(4H)-one誘導体, 及び関連化合物の合成と抗不安作用
- 縮合Pyridazine誘導体の合成研究(第1報)2-Substituted-4,4a, 5,6-tetrahydrobenzo[h]cinnolin-3(2H)-one誘導体, 及び関連化合物の合成とBenzodiazepine受容体親和性
- Alschomine and Isoalschomine, New Alkaloids from the Leaves of Alstonia scholaris
- VERSATILE ROUTES TO CHIRAL 4-SUBSTITUTED 2-OXAZOLIDINONES AND α-AMINO ACIDS. USE OF CHIRON, [4+2] CYCLOADDUCTS OF DIALKYL AZODICARBOXYLATES AND 2-OXAZOLONES
- STEREOSELECTIVE OXIDATION OF 2-(4-CHILOROPHENYL)-4a, 5-DIHYDRO-2H-(1)BENZOTHIOPYRANO[4,3-c]PYRIDAZIN-3(4H)-ONE TO SULFOXIDE