選択毒性に関する研究(第7報) : チオールエステル類化合物の殺線虫性

概要

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Examinations were made on the correlation between chemical structure of thiol esters and their corresponding related compounds and the biological activity centering around nematocidal activity, especially their action against insects, fungi, bacteria, and plant tissues. Examinations were also made on their action mechanism at the enzyme level. Tendency of nematocidal activity of R-COS-Ph(-Y) (A) and (X-)Ar-COS-Ph(-Y) (B) compounds examined by soaking method showed that phenyl thiobenzoate of (B) series had a stronger activity. Substitution of -COS-in (B) compounds with -COO- or -CONH- resulted in decrease of nematocidal activity. Substitution of phenyl in (B) series compounds with a hetero ring, such as thiophene and pyridine, resulted in strong efficacy. Comparison of the activity in various biological phases showed that these compounds have selective toxicity of considerable structural specificity in their toxicity against insects and plants. The compounds were also found to possess inhibition against alcohol dehydrogenase activity and histidine decarboxylase. This inhibitory effect is not nonspecific and it was assumed that the factor lies in the specific inhibition against SH enzyme.
社団法人日本薬学会の論文
1969-09-25