選択毒性に関する研究(第1報) : アルキルジチオカーバメイト化合物の構造-抗菌活性

概要

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Relationship between structure and antimicrobial activity of alkyl dithiocarbamates was examined. The compounds [A] of (A, R)-N-C (=S)-S-C (=Y)-X-Ar type generally possess a wide antimicrobial spectrum, and the activity is the strongest when both A and R are methyl groups. In the four combinations with X and Y as S or O, the antimicrobial activity falls in the order of SS, SO or OS, and OO (labile). As the compounds with the strongest antimicrobial activity, 2-or 4-chlorophenyl-N, N-dimethylthiocarbamoyl dithiocarbamate and 2-or 4-chlorophenyl-N, N-dimethylthiocarbamoyl dithiocarbamate were identified. In general, [A]-type compounds are labile and tend to change into [B] compounds of (A, R)-N-C (=S)-X-Ar type, losing their antimicrobial activity. However, substitution of A and Ar with aryl groups and R with methyl group suddenly give selective antimicrobial activity to such compounds.
社団法人日本薬学会の論文
1968-02-25