ラット横隔膜でのグルコースからのグリコーゲン合成におけるアノマー優位性

概要

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Our previous work has indicated that there is no significant difference between the rates of glycogen synthesis from the α and β anomers of glucose in the rat diaphragm. The present study was performed to prove this fact by means of mathematical estimation of the glycogen synthesis rate. In order to obtain the values of parameters necessary for the mathematical estimation, we measured the rate of glucose uptake by the rat diaphragm, the contents of glucose and glucose-6-phosphate in the tissue, and their mutarotational rates. As a result of calculation, the rate of glycogen synthesis from α-D-glucose was shown to be indistinguishably similar to that from β-D-glucose, supporting our previous data. During the course of this study, the presence of compartmentation of glucose metabolism in the rat diaphragm was also suggested.
公益社団法人日本薬学会の論文
1987-10-25