TPN液中Thiamine安定性と推定投与量に及ぼす光と亜硫酸水素イオンの影響

概要

論文の詳細を見る
In the present study, the authors examined the change in thiamine content of a TPN fluid under clinical conditions, obtained Integrated Dose in Period (IDP) values and compared this data with IDP values calculated on the basis of stability data in the literature. We also determined the bisulfite ion concentration that affected the stability of thiamine in the TPN fluid. Our results showed that, 62.5% and 59.5% of the thiamine in the TPN fluid remained 24 hours after its preparation under light and dark conditions, respectively. The bisulfite ion concentration decreased from 0.279 mg/mL to 0.177mg/mL under light and from 0.284 mg/mL to 0.227 mg/mL under dark conditions. While the IDP values that we obtained were less than those calculated on the basis of the literature, they were still over the daily thiamine requirement (1.3 mg), even after 48 hours. In conclusion, the authors demonstrated that the thiamine content of a TPN fluid could be maintained at an adequate level following preparation under the conditions of the daily clinical setting, and that one can rely on stability data from the literature for the purpose of estimating IDPs for vitamins.
日本医療薬学会の論文
2004-04-10