dl-α-トコフェロール2-L-アスコルビン酸リン酸ジエステルカリウム塩(EPC-K)の安定性に関する研究

概要

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A compound having structures of both vitamines E and C, L-ascorbic acid dl-α-tocopherol phosphoric acid diester potassium salt (EPC-K), which was proven to have both anti-oxidative and moisturizing effects, has been formulated in the quasi drug hair growing products to mainly prevent dandruff and itching which may be one of the causes for the hair loss. Stabilities of EPC-K in 75% ethanolic solutions with various pHs (2-10) were examined extensively by storing them at 50℃ for 30d and by sunlight exposure for 30d. Decomposition of EPC-K was only observed under pH 2 at a level of 50% and under sunlight exposure at 25% level. A main decomposition product was identified as tocopheryl phosphate (EP), suggesting that a decomposition route was through hydrolysis. EPC-K was found to decompose by as much as 20% under 30d storage at 50℃ when the concentration of the aqueous ethanolic solution was 0-30%. ^1H, ^<13>C and ^<31>P-NMR studies in addition to a micelle formation test using pyrene fluorescent probe revealed that EPC-K formed a micelle at such low concentration of ethanol, which was assumed to be a cause for unstableness of EPC-K in that range. Hydrolytic decomposition of EPC-K was found by the reaction rate study to be a pseudo first order reaction with activation energy of 16.98 kcal/mol.
1994-07-25