高速液体クロマトグラフィーによる医薬部外品中のグリチルリチン酸塩の定量における異常拳動の解明

概要

論文の詳細を見る
Glycyrrhizinates such as monoammonium and dipotassium glycyrrhizinates which are extracted from licorice, convertea to easily water-soluble salts and refined have been formulated in many quasi-drug products as an anti-inflammatory agent. A quantitative analysis of glycyrrhizinates in quasi-drug products has usually and successfully been carried out by high performance liquid chromatography (HPLC). However, a slightly higher value than the actual content has sometimes been observed in daily analysis. As the result of our various studies to investigate these phenomena, we finally found that a minor constituent in commercial glycyrrhizinates, which was identified as monomethyl glycyrrhizinate, was hydrolyzed after they were formulated in quasi-drug products and converted to glycyrrhizin which in turn was determined by HPLC as a higher value.
社団法人日本薬学会の論文
1992-07-25