ペンタクロロベンゼンとその代謝物のラットにおける体内分布

概要

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The distributions of pentachlorobenzene (PECB) and its metabolite after oral administration of PECB were investigated in rats. A major metabolite of PECB in the liver was pentachlorophenol (PCP), which was also detected in the blood, urine and feces. After PECB administration, PECB content in the liver reached the maximum level at 8-24 h, then decreased, while PCP content in the liver reached maximum at 24-48 h. Changes of PECB and PCP concentrations in the blood were similar to those in the liver. When PECB distribution was examined at 8,24 and 144 h after PECB administration, PECB content in the kidney was higher and that in the spleen was lower than those in other organs tested. PECB content in adipose tissue was markedly higher than those in other organs. The ratio of PECB content in adipose tissue to those in other organs increased as time. In contrast with PECB, PCP content was the highest in the liver and not detected in adipose tissue. Different distributions of PECB and PCP were also observed in the blood. PECB was mainly present in blood cells, while PCP mainly detected in the plasma.
公益社団法人日本薬学会の論文
1989-10-31