四塩化炭素投与ラットの肝臓過酸化脂質の増加と血清過酸化脂質の低下並びにそれに対するビタミンEの投与効果

概要

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Carbon tetrachloride (CCl_4) was administered to rats at a single dose of 2500 mg/kg or a daily dose of 200 mg/kg for 9 days, and the changes of serum lipid peroxide levels and their relation to hepatic lipid peroxide levels were investigated. The effect of vitamin E (E : α-Tocopheryl acetate, 80 mg/kg) administration on the lipid peroxide levels was also examined. CCl_4 administration increased the levels of TBARS and triglyceride in liver and GOT and GPT activities in serum, while TBARS levels in serum were decreased. In case of the 9-day dosage of CCl_4, the decrease of serum lipids was also observed. These results suggested that the increase of liver TBARS levels did not reflect the serum TBARS levels. Simultaneous administration of E with CCl_4 inhibited the increase in TBARS levels in the liver. E administration also significantly inhibited the increase of serum GOT and GPT following the 9-day dosage of CCl_4.
日本ビタミン学会の論文
1991-01-25