グリシンに対する次亜塩素酸の作用(第2報)クロルグリシンの生成とその分解機構

概要

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The mechanism of reaction of glycine with hypochlorite was investigated under neutral conditions in phosphate buffer. At the first stage in this reaction, monochloroglycine was formed at any molar ratio of glycine and hypochlorite. When the amount of hypochlorite exceeded the equimolar of glycine, dichloroglycine was formed from monochloroglycine. Although monochloroglycine was fairly stable, dichloroglycine was labile, so that it underwent decarboxylation and dehydrochlorination to form cyanide, as the corresponding nitrile. Cyanide thus formed was chlorinated rapidly by combined residual chlorine in chloroglycine molecules or by excess hypochlorite, and converted to cyanogen chloride. One mole glycine needed three moles of hypochlorite for the formation of the equivalent cyanogen chloride. Cyanogen chloride was decreased by the subsequent addition of excess hypochlorite. Total chlorine consumed by 1 mol glycine was 4.5 mol.
社団法人日本薬学会の論文
1983-12-31