二酸化塩素によるポリオウイルスの不活化作用

概要

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The inactivation rate of poliovirus (Lsc, 2ab strain) suspended in a cell maintenance medium (MEM) and in phosphate buffer salt solution (PBS) with chlorine dioxide (ClO_2), and chlorite ion (ClO_2^-), of 0.4,1.0 and 2.0 mg/l as available chlorine were studied at pH 7 and 20℃. The residual ClO_2 and ClO_2^- formed in the test solution were determined. The decrease of residual ClO_2 and the formation of ClO_2^- in MEM virus suspension were greater than those in PBS virus suspension. In the lower concentration of ClO_2 (0.4 mg/l), the decrease of ClO_2 in MEM virus suspension resulted in a slower inactivation. With 2.0 mg/l of ClO_2,99% of the virus was inactivated in about 2 min in both virus suspensions. Chlorite ion (2.0 mg/l) had little effect on the inactivation of the virus in 15 min contact. The inactivation rate with 2.0 mg/l of ClO_2 was almost the same with that with 0.4 mg/l of HOCl reported in a previous paper. The similar inactivation efficiency may be due to almost the same redox potentials (E_0 (V)) of ClO_2 and HOCl, and due to the equal oxidizing capacities of 2.0 mg/l of ClO_2 and 0.4 mg/l of HOCl in the test solution in the neutral pH range.
社団法人日本薬学会の論文
1993-12-31