Genotoxicity of Environmental Mutagens in a Drosophila DNA-repair Test

概要

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Genotoxicity of 13 mutagens was tested by a Drosophila DNA-repair test. Although strong mutagens such as aflatoxin B1,sterigmatocystin, 2-(2-furyl)-3-(5-nitro-2-furyl) acrylamide, 2-amino-3-methylimidazo [4,5-f] quinoline, 2-amino-3,4-dimethylimidazo [4,5-f] quinoline, 2-amino-3,8-dimethylimidazo [4,5-f] quinoxaline, 3-amino-1,4-dimethyl-5H-pyrido [4,3-b] indole, 3-amino-1-methyl-5H-pyrido [4,3-b] indole, and 1,8-dinitropyrene showed positive results, methylglyoxal, formaldehyde, kojic acid, and hydrogen peroxide gave negative outcome. The ability of larval S9 fraction to activate or inactivate mutagens was monitored in the umu test. In the presence of larval S9,AFB1,IQ, Trp-P-1 and Trp-P-2 induced the umu gene expression, depending on their genotoxicities in the DNA repair test. In contrast, the genotoxicities of AF-2 and methylglyoxal in the umu test were diminished in the presence of S9 fraction. These results suggest that the genotoxic potency of a compound in the repair test is affected at least partly by metabolism in the larvae.
公益社団法人日本薬学会の論文
1993-12-31