Effects of Insulin and 1α-Hydroxy Vitamin D_3 on Streptozotocin-Induced Diabetic Rats Fed a Low Zinc Diet

概要

論文の詳細を見る
Streptozotocin-induced diabetic rats (LZ-DM rats) developed nephrocalcinosis after being fed a low zinc diet for 4 weeks. However, administration of 1α-hydroxy vitamin D_3 (1-OHD_3) or insulin inhibited the formation of nephrocalcinosis.The urinary calcium level increased when 1-OHD_3 was administered to these rats, but decreased in the group receiving insulin. It was also observed that the femur recovered its hardness when insulin was administered, although the hardness in the LZ-DM rats remained lower than that of the control rats. Rat femur hardness, however, did not completely recover with 1-OHD_3 treatment.These results indicate that the effects of insulin and 1-OHD_3 differ, even though nephrocalcinosis was reduced by administration of either insulin or 1-OHD_3. It appears that insulin assists bone formation, and the 1-OHD_3 hastens calcium excretion.
社団法人日本薬学会の論文
1993-05-15