マウスにおけるシスプラチン腎障害の酸化的障害に及ぼすアロプリノールの影響

概要

論文の詳細を見る
The effects of allopurinol (Allop) on the lipid peroxidation in the nephrotoxicity of an antitumor drug, cisplatin (CDDP) were studied in mice. CDDP was administered intraperitoneally to two groups (CDDP+Allop group and CDDP+CMC-Na group) at single doses of 10 mg/kg, and mice were sacrificed 3 days after CDDP administration. The body weights of the CDDP-administered group gradually decreased to approximately 78% of the values of the control group (saline+Allop group and saline+CMC-Na group) within 3 days. Plasma urea nitrogen and creatinine, especially in the CDDP+Allop group, increased after 3 days. Lipid peroxides in the blood and kidney were monitored by measuring the production of malondialdehyde (MDA), which increased in the CDDP+CMC-Na group. On the other hand, MDA levels in the CDDP+Allop group increased in the kidney but remained unchanged in the blood. Changes were observed in tissue glutathione (reduced form, GSH; oxidized form, GSSG) levels in the CDDP+Allop group but not in the CDDP+CMC-Na group. Histomorphological examination demonstrated the degeneration of the proximal tubuli in the CDDP-administered groups. Especially in the CDDP+Allop group, the increase of mesangium cells in the glomeruli was observed. From these results, it was suggested that Allop was not able to inhibit CDDP-induced lipid peroxidation in the kidney, and the kidney function became more severely impaired by the administration of Allop.
社団法人日本薬学会の論文
1999-12-01

マウスにおけるシスプラチン腎障害の酸化的障害に及ぼすアロプリノールの影響

スポンサーリンク

概要

著者

関連論文

スポンサーリンク