Differential Effects of Cytotoxic Drugs on Mortal and Immortalized B-Lymphoblastoid Cell Lines from Normal and Werner's Syndrome Patients
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概要
- 論文の詳細を見る
We studied the effects of nine cytotoxic drugs on three groups of B-lymphoblastoid cell lines transformed by Epstein-Barr virus (EBV) : group 1,mortal cell lines from normal individuals; group 2,immortalized cell lines from normal individuals with strong telomerase activity; group 3,mortal cell lines from Werner's syndrome (WS) patients. Aminoglycoside antibiotics and alkylating drugs showed significantly stronger cytotoxic effects on immortalized cell lines than on mortal cell lines or the cell lines before immortalization. In contrast, topoisomerase II inhibitors showed no difference or they tended to be less cytotoxic to immortalized cell lines. Mortal cell lines from normal individuals and WS patients showed no difference in sensitivity against all the drugs examined except for the topoisomerase I inhibitor, camptothecin, which had a stronger cytotoxic effect on WS cell lines than other cell lines. We discuss the mechanisms underlying these cytotoxic effects.
- 公益社団法人日本薬学会の論文
- 1998-03-15
著者
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SUGIMOTO Masanobu
GeneCare (previously AGENE) Research Institute
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Furuichi Y
Genecare Research Institute
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Furuichi Yasuhiro
ジーンケア研究所
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Sugimoto M
Genecare Research Institute
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Sugimoto Masanobu
ジーンケア研究所
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FURUICHI Yasuhiro
AGENE Research Institute
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GOTO Makoto
Tokyo Metro. Otsuka Hosp.
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Furuichi Yasuhiro
Genecare Research Institute Co. Ltd.:core Research For Evolution Science And Technology Japan Scienc
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Goto M
Toin University Of Yokohama Faculty Of Medical Engineering Department Of Clinical Engineering Divisi
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Okada Masako
Agene Research Institute
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SUGIMOTO Masanobu
AGENE Research Institute
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