Effects of Tea from Turnera ulmifolia L. on Mouse Gastric Mucosa Support the Turneraceae as a New Source of Antiulcerogenic Drugs

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概要

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• Turnera ulmifolia is a plant belonging to the family Turneraceae, popularly known in Brazil as chanana. This species is distributed from Guyana to southern Brazil where it is considered a weed. The plant occurs in tropical rain forest, fields, and gardens. Chanana tea is used in Brazilian folk medicine for the treatment of diseases related mainly to gastric dysfunction including gastric and duodenal ulcers. In this study, the ability of a lyophilized infusion, as an aqueous fraction (AqF) of the aerial parts of T. ulmifolia, was investigated for its ability to prevent ulceration of the gastric and duodenal mucosa was examined in mice and rats, respectively. The AqF significantly reduced the formation of lesions associated with HCI/ethanol administration by 39% and 46%, respectively, at doses of 500 mg/kg and 1000 mg/kg, p.o. The AqF also significantly reduced the incidence of gastric lesions induced by a combination of indomethacin and bethanechol by 58% and 72% at doses of 500 mg/kg and 1000 mg/kg, respectively. In stress-induced gastric ulcer, the inhibition by the AqF was 48%, 57%, and 58% at doses of 250 mg/kg, 500 mg/kg, and 1000 mg/kg, respectively (p<0.05). A pyloric ligature experiment showed that the highest dose of the AqF significantly affected the gastric juice parameters by increasing the pH from 2.5 (control) to 5.3 and decreasing the acid output from 11.3 (control) to 3.7 mEq/ml/4 h. The AqF had no significant effect on duodenal ulcers induced by cysteamine. Preliminary phytochemical screening confirmed that fiavonoids were the major constituents of the AqF of T. ulmifolia. These results indicate that this extract has a significant antiulcerogenic effect, as popularly believed.

• 公益社団法人日本薬学会の論文
• 2002-04-01

著者

• Souza Brito

  Departamento De Morfologia Instituto De Biociencias Universidade Estadual Paulista (unesp)

• Gracioso Juliano

  Botucatu Sao Paulo Brazil Departamento De Fisiologia E Biofisica Instituto De Biologia Universidade

• Hiruma-lima Clelia

  Departamento De Fisiologia Instituto De Biociencias Universidade Estadual Paulista (unesp)

• Vilegas Wagner

  Departamento De Quimica Orĝanica Instituto De Quimica Universidade Estadual Paulista (unesp)

• Vilegas W

  Univ. Estadual Paulista (unesp) Sp Bra

• GRACIOSO Juliano

  Departamento de Fisiologia e Biofisica, Instituto de Biologia, Universidade Estadual de Campinas

• VILEGAS Wagner

  Universidade Estadual Paulista (UNESP)

• HIRUMA LIMA

  Departamento de Fisiologia, Instituto de Biociencias, Universidade Estadual Paulista (UNESP)

• Hiruma Lima

  Departamento De Fisiologia Instituto De Biociencias Universidade Estadual Paulista (unesp)

• Hiruma Lima

  Departamento De Fisiologia Instituto De Biociencias

• Gracioso Juliano

  Departamento De Fisiologia E Biofisica Instituto De Biologia Universidade Estadual De Campinas (unic

• De Souza

  Departamento De Bioquimica Centro De Ciencias Biologicas (ccb) Universidade Federal De Pernambuco (ufpe)

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