Natural trans-Crotonin : The Antiulcerogenic Effect of Another Diterpene Isolated from the Bark of Croton cajucara BENTH

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概要

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• The nor-clerodane diterpene trans-crotonin isolated from the bark of Croton cajucara BENTH. was investigated for its ability to prevent the formation of gastric-mucosa ulceration in different experimental models in mice. The results obtained from crotonia were compared with those obtained with another diterpene, DHC (trans-dehydrocrotonin) in the same models. When previously administered (p.o.) at the dose of 100 mg/kg, crotoain, as well as DHC, significantly reduced (p<0.05) gastric injury induced by stress (72, 67%), indomethacin/bethanechol (78, 29%) and pylorus ligature (35, 30%). In the HCI/ethanol-induced gastric ulcer model, at oral doses of 100 and 250 mg/kg, crotonin significantly prevented (p<0.05) the formation of gastric lesions by 51 and 56%, respectively, when compared to the control group. Gastric injury was also of significantly less magnitude in the DHC treatment group (p<0.05). In the pylorus-ligature model, crotonin (p.o.), like cimetidine, increased the volume of gastric juice when compared to the control group (p<0.05). No significant modifications where found in gastric parameters such as pH or total acid content after oral crotonin treatment. However, systemic alterations were observed when crotonin (100 mg/kg) was previously administered intraduodenally to mice. We observed significant changes (p<0.001) in gastric-juice parameters such as an increase in volume and a decrease in gastric acidity. Those pre-treated with crotonin as well as with DHC did not increase free mucus production (p>0.05). The results suggest that crotonin presents a significant anti-ulcer effect when assessed in these ulcer-in-duced models. As with DHC, the antiulcerogenic effects of crotonin are probably related to anti-secretory or/and gastroprotective properties of this substance. In light of results obtained with DHC and natural trans-crotonin in the present study, we concluded that the A-ring of both diterpenes is not directly involved in the antiulcerogenic activity.

• 公益社団法人日本薬学会の論文
• 2002-04-01

著者

• Souza Brito

  Departamento De Morfologia Instituto De Biociencias Universidade Estadual Paulista (unesp)

• Gracioso Juliano

  Botucatu Sao Paulo Brazil Departamento De Fisiologia E Biofisica Instituto De Biologia Universidade

• Hiruma-lima Clelia

  Departamento De Fisiologia Instituto De Biociencias Universidade Estadual Paulista (unesp)

• TOMA Walber

  Botucatu, Sao Paulo, Brazil, Departamento de Fisiologia e Biofisica, Instituto de Biologia, Universi

• Albino de

  Botucatu, Sao Paulo, Brazil, Departamento de Fisiologia e Biofisica, Instituto de Biologia, Universi

• BATISTA Leonia

  Botucatu, Sao Paulo, Brazil, Departamento de Fisiologia e Biofisica, Instituto de Biologia, Universi

• MAGRI Luciana

  Botucatu, Sao Paulo, Brazil, Departamento de Fisiologia e Biofisica, Instituto de Biologia, Universi

• Bensuaski de

  Botucatu, Sao Paulo, Brazil, Departamento de Fisiologia e Biofisica, Instituto de Biologia, Universi

• SOARES Fernanda

  Botucatu, Sao Paulo, Brazil, Departamento de Fisiologia e Biofisica, Instituto de Biologia, Universi

• NUNES Domingos

  Departamento de Quimica, Universidade Estadual de Ponta Grossa

• SOUZA BRITO

  Botucatu, Sao Paulo, Brazil, Departamento de Fisiologia e Biofisica, Instituto de Biologia, Universi

• Batista Leonia

  Departamento De Ciencias Farmaceuticas Centra De Ciencias Da Saude Universidade Federal Da Paraiba (

• Toma Walber

  Departamento De Fisiologia E Biofisica Institute De Biologia Universidade Estadual De Campinas (unic

• Albino De

  Botucatu Sao Paulo Brazil Departamento De Fisiologia E Biofisica Instituto De Biologia Universidade

• Bensuaski De

  Botucatu Sao Paulo Brazil Departamento De Fisiologia E Biofisica Instituto De Biologia Universidade

• Magri Luciana

  Botucatu Sao Paulo Brazil Departamento De Fisiologia E Biofisica Instituto De Biologia Universidade

• Nunes Domingos

  Departamento De Quimica Universidade Estadual De Ponta Grossa

• Soares Fernanda

  Botucatu Sao Paulo Brazil Departamento De Fisiologia E Biofisica Instituto De Biologia Universidade

• Gracioso Juliano

  Departamento De Fisiologia E Biofisica Instituto De Biologia Universidade Estadual De Campinas (unic

• de Souza

  Botucatu, Sao Paulo, Brazil, Departamento de Fisiologia e Biofisica, Instituto de Biologia, Universidade Estadual de Campinas,b Campinas

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• Natural trans-Crotonin : The Antiulcerogenic Effect of Another Diterpene Isolated from the Bark of Croton cajucara BENTH
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