Evaluation of Strychnos pseudoquina ST. HIL. Leaves Extract on Gastrointestinal Activity in Mice

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概要

• 論文の詳細を見る

• Strychnos pseudoquina ST. HIL. (Loganiaceae) was investigated for its ability to protect the gastric mucosa against injuries caused by non-steroidal anti-inflammatory drugs (piroxicam) and a necrotizing agent (HCl/EtOH) in mice. The MeOH extract and enriched alkaloidic fraction (EAF) provided significant protection in experimental models wheer used at doses of 250 and 1000mg/kg. In vivo tests were carried out to evaluate for possible toxic effects and no mortality was observed up to the 5g/kg dose level. Phytochemical investigation led to the isolation of a new indole alkaloid, which elucidated the observed pharmacological effects.

• 社団法人日本薬学会の論文
• 2005-08-01

著者

• Hiruma-lima Clelia

  Departamento De Fisiologia Instituto De Biociencias Universidade Estadual Paulista (unesp)

• Da Silva

  Department Of Organic Chemistry Instituto De Quimica De Araraquara Sao Paulo State University (unesp

• Vilegas Wagner

  Departamento De Quimica Orĝanica Instituto De Quimica Universidade Estadual Paulista (unesp)

• Vilegas W

  Univ. Estadual Paulista (unesp) Sp Bra

• Dos Santos

  Department Of Organic Chemistry Instituto De Quimica De Araraquara Sao Paulo State University (unesp

• SANNOMIYA Miriam

  Department of Organic Chemistry, Instituto de Quimica de Araraquara, Sao Paulo State University (UNE

• SILVA Marcelo

  Departamento de Quimica Organica; Instituto de Quimica

• RAFACHO Bruna

  Departamento de Fisiologia, Instituto de Biociencias

• ROCHA Lucia

  Departamento de Fisiologia, Instituto de Biociencias

• SANTOS Lourdes

  Departamento de Quimica Organica; Instituto de Quimica

• SOUZA-BRITO Alba

  Departamento de Fisiologia e Biofisica, Instituto de Biologia

• Souza-brito Alba

  Departamento De Fisiologia E Biofisica Instituto De Biologia

• Rocha Lucia

  Departamento De Fisiologia Instituto De Biociencias

• Rafacho Bruna

  Departamento De Fisiologia Instituto De Biociencias

• Silva Marcelo

  Departamento De Quimica Organica; Instituto De Quimica:departamento De Farmacos E Medicamentos Facul

• Sannomiya Miriam

  Department Of Organic Chemistry Instituto De Quimica De Araraquara Sao Paulo State University (unesp

• Da Silva

  Departamento De Biologia Celular Universidade De Brasilia

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