Constituents and Antiulcer Effect of Alchornea glandulosa : Activation of Cell Proliferation in Gastric Mucosa during the Healing Process(Pharmacology)

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概要

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• Alchornea glandulosa (Euphorbiaceae) is a plant used in folk medicine as an antiulcer agent. Rats pretreated with methanolic extract obtained from the leaves of A. glandulosa (AG) showed a dose-dependent effect and significant reduction of gastric ulcers induced by absolute ethanol at the doses of 500 (57%) and 1000 mg/kg (85%) in relation to the control group. Pretreatment of mice with AG (500, 1000 mg/kg, p.o.) showed dose-de-pendent activity and significantly decreased the severity of lesions caused by HCl/ethanol and by non steroidal anti infiammatory drug-induced gastric lesions. Pretreatment with AG also induced antisecretory action via local and systemic routes and a significant decrease in the total gastric acid content. The gastroprotective effects of AG involved the participation of nitric oxide and increased levels of endogenous sulfhydryl compounds, which are defensive mechanisms of the gastrointestinal mucosa against aggressive factors. The ability of AG to heal gastric ulcers was evaluated after 14 consecutive days of treatment. The results showed that single oral administrations of AG (250 mg/kg/once daily) potently stimulates gastric epithelial cell proliferation that contributes to the accelerated healing of gastric ulcers induced by acetic acid. In addition, no subacute toxicity (body weight gain, vital organs, and serum biochemical parameters) was observed during treatment with AG. Phytochemical investigation of AG led to the isolation of myricetin-3-0-α-L-rhamnopyranoside, quercetin-3-0-α-L-arabinopyranoside, quercetin-3-0-β-D-galactopyranoside, quercetin, amentoflavone, methyl gallate, gallic acid, and pterogynidine. We also established the phytochemical profile of AG with the quantification of total phenolic compounds. These compounds may contribute to the observed antiulcerogenic effects of AG.

• 公益社団法人日本薬学会の論文
• 2007-03-01

著者

• Souza Brito

  Departamento De Morfologia Instituto De Biociencias Universidade Estadual Paulista (unesp)

• Hiruma-lima Clelia

  Departamento De Fisiologia Instituto De Biociencias Universidade Estadual Paulista (unesp)

• Vilegas Wagner

  Departamento De Quimica Orĝanica Instituto De Quimica Universidade Estadual Paulista (unesp)

• Vilegas W

  Univ. Estadual Paulista (unesp) Sp Bra

• Calvo Tamara

  Departamento De Quimica Organica Instituto De Quimica Universidade Estadual Paulista (unesp)

• LIMA Zeila

  Departamento de Fisiologia, Instituto de Biociencias, Universidade Estadual Paulista (UNESP)

• SILVA Janaina

  Departamento de Fisiologia, Instituto de Biociencias, Universidade Estadual Paulista (UNESP)

• BALLESTEROS Katia

  Departamento de Fisiologia, Instituto de Biociencias, Universidade Estadual Paulista (UNESP)

• PELLIZZON Claudia

  Departamento de Morfologia, Instituto de Biociencias, Universidade Estadual Paulista (UNESP)

• TAMASHIRO Jorge

  Departamento de Botanica, Instituto de Biologia, Universidade Estadual de Campinas (UNICAMP)

• TAKAHIRA Regina

  Departamento de Clinica Veterindria, Faculdade de Medicina Veterinria e Zootecnia, Universidade Esta

• Silva Janaina

  Departamento De Fisiologia Instituto De Biociencias Universidade Estadual Paulista (unesp)

• Takahira Regina

  Departamento De Clinica Veterindria Faculdade De Medicina Veterinria E Zootecnia Universidade Estadu

• Lima Zeila

  Departamento De Fisiologia Instituto De Biociencias Universidade Estadual Paulista (unesp)

• Tamashiro Jorge

  Departamento De Botanica Instituto De Biologia Universidade Estadual De Campinas (unicamp)

• Ballesteros Katia

  Departamento De Fisiologia Instituto De Biociencias Universidade Estadual Paulista (unesp)

• Pellizzon Claudia

  Departament Of Morphology Instituto De Biociencias Sao Paulo State University (unesp)

• Calvo Tamara

  Departamento De Quimica Organica Instituto De Quimica Unesp

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