Effect of the Isocoumarin Paepalantine on the Luminol and Lucigenin Amplified Chemiluminescence of Rat Neutrophils
スポンサーリンク
概要
- 論文の詳細を見る
Paepalantine (9,10-dihydroxy-5,7-dimethoxy-1H-naphto(2,3c)pyran-1-one), a natural isocoumarin isolated from the capitula of Paepalanthus bromelioides (Eriocaulaceae), was assessed for its effect on the respiratory burst (zymosan-stimulated luminol-enhanced chemiluminescence and PMA-stimulated lucigenin-enhanced chemiluminescence) of polymorphonuclear neutrophils in vitro. Special attention was devoted to establishing the IC_<50> for neutrophils. Paepalantine was able to decrease luminol and iucigenin chemiluminescence, reflecting an inhibitory effect on the respiratory burst, with an ED_<50> of 0.44±0.05 and 0.84±0.15μg/ml, respectively. A cell-free system was performed with paepalantine on myeloperoxidase/H_2O_2 and myeloperoxidase/H_2O_2/Cl^- systems. Paepalantine inhibited luminol oxidation in both systems. This inhibition was related to the interaction of paepalantine-myeloperoxidase and its scavenger effect on HOCI.
- 公益社団法人日本薬学会の論文
- 2003-06-01
著者
-
Vilegas Wagner
Departamento De Quimica Orĝanica Instituto De Quimica Universidade Estadual Paulista (unesp)
-
Vilegas W
Univ. Estadual Paulista (unesp) Sp Bra
-
Da Fonseca
State Univ. Sao Paulo (unesp) Sp Bra
-
Raddi Maria
Faculdade De Ciencias Farmaceuticas De Araraquara Universidade Estadual Paulista "julio De Mesq
-
KITAGAWA Rodrigo
Institute de Quimica de Araraquara, Universidade Estadual Paulista "Julio de Mesquita Filho." Rua Pr
-
VILEGAS Wagner
Institute de Quimica de Araraquara, Universidade Estadual Paulista "Julio de Mesquita Filho." Rua Pr
-
RADDI Maria
Facnldade de Ciencias Farmaceuticas de Araraquara, Universidade Estadual Paulista Julio de Menquita
-
KHALIL Najeh
Facnldade de Ciencias Farmaceuticas de Araraquara, Universidade Estadual Paulista Julio de Menquita
-
da FONSECA
Facnldade de Ciencias Farmaceuticas de Araraquara, Universidade Estadual Paulista Julio de Menquita
-
Kitagawa Rodrigo
Institute De Quimica De Araraquara Universidade Estadual Paulista "julio De Mesquita Filho.&quo
-
Khalil Najeh
Facnldade De Ciencias Farmaceuticas De Araraquara Universidade Estadual Paulista Julio De Menquita F
関連論文
- Flavonoids and a Naphthopyranone from Eriocaulon ligulatum and Their Mutagenic Activity
- Evaluation of Strychnos pseudoquina ST. HIL. Leaves Extract on Gastrointestinal Activity in Mice
- Antiulcerogenic Activity of Four Extracts Obtained from the Bark Wood of Quassia amara L. (Simaroubaceae)
- Effects of Tea from Turnera ulmifolia L. on Mouse Gastric Mucosa Support the Turneraceae as a New Source of Antiulcerogenic Drugs
- Constituents and Antiulcer Effect of Alchornea glandulosa : Activation of Cell Proliferation in Gastric Mucosa during the Healing Process(Pharmacology)
- Gastric Antiulcer Activity of Syngonanthus arthrotrichus SILVEIRA (Pharmacology)
- Determination of herbicides and a metabolite in human urine by liquid chromatography-electrospray ionization mass spectrometry
- Release of Intermediate Reactive Hydrogen Peroxide by Macrophage Cells Activated by Natural Products
- Studies on Anti-Allergic Constituents in the Leaves and Stems of Anchietia salutaris var. martiana (Violaceae)
- Inhibition of Hydrogen Peroxide, Nitric Oxide and TNF-α Production in Peritoneal Macrophages by Ethyl Acetate Fraction from Alchornea glandulosa(Miscellaneous)
- A New Cytotoxic Naphthoquinone from Paepalanthus latipes
- Effect of the Isocoumarin Paepalantine on the Luminol and Lucigenin Amplified Chemiluminescence of Rat Neutrophils