Inhibition of Hydrogen Peroxide, Nitric Oxide and TNF-α Production in Peritoneal Macrophages by Ethyl Acetate Fraction from Alchornea glandulosa(Miscellaneous)
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概要
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The effects of Alchornea glandulosa ethyl acetate fraction (AGF) on hydrogen peroxide (H_2O_2), nitric oxide (NO) and tumor necrosis factor-α(TNF-α) production in peritoneal macrophages activated with lipopolysaccharide (LPS) or phorbol myristate acetate (PMA) were investigated. Analysis by thin layer chromatography (TLC) of AGF showed several constituents, including flavonoids, which may have anti-inflammatory activity. Inhibitory effects of the fraction in H_2O_2 and NO production ranged from 8.59±7.84% to 70.56±4.16% and from 16.06±3.65% to 38.73±3.90%, respectively. The TNF-α production was only partially inhibited in the tested concentrations (12.21±6.23%-15.16±0.96%). According to these results, it is suggested that AGF has anti-inflammatory activity. This medicinal plant may have therapeutic potential in the control of inflammatory disorders.
- 公益社団法人日本薬学会の論文
- 2005-09-01
著者
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Vilegas Wagner
Departamento De Quimica Orĝanica Instituto De Quimica Universidade Estadual Paulista (unesp)
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Calvo Tamara
Departamento De Quimica Organica Instituto De Quimica Universidade Estadual Paulista (unesp)
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Vilegas Wagner
Departamento De Quimica Organica Instituto De Quimica Unesp
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CARLOS Iracilda
Departamento de Analises Clinicas, Faculdada de Ciencias Farmaceuticas, Universidada Estadual Paulis
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Carlos Iracilda
Departamento De Analises Clinicas Faculdade De Ciencias Farmaceuticas Unesp-universidade Estadual Pa
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Carlos Iracilda
Departamento De Analises Clinicas Faculdada De Ciencias Farmaceuticas Universidada Estadual Paulista
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LOPES Flavia
Departamento de Analises Clinicas, Faculdade de Ciencias Farmaceuticas, UNESP-Universidade Estadual
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Lopes Flavia
Departamento De Analises Clinicas Faculdade De Ciencias Farmaceuticas Unesp-universidade Estadual Pa
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Calvo Tamara
Departamento De Quimica Organica Instituto De Quimica Unesp
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