Thalidomide Analogs from Diamines : Synthesis and Evaluation as Inhibitors of TNF-α Production
スポンサーリンク
概要
- 論文の詳細を見る
Fourteen thalidomide analogs bearing two phthalimido units were prepared in high yields (83-94%) by condensation of different diamines with phthalic or 3-nitrophthalic anhydride. An in vitro investigation of the compounds as inhibitors of the TNF-α production was performed. The inhibition was higher for compounds bearing amino and nitro groups and was modulated by increasing the size of the spacers between the phthalimide groups.
- 公益社団法人日本薬学会の論文
- 2007-02-01
著者
-
De Almeida
Departamento De Analises Clinicas E Toxicologicas Faculdade De Ciencias Farmaceuticas Universidade D
-
Mattos Ana
Laboratory Of Immunology Department Of Parasitology Microbiology And Immunology Icb Federal Universi
-
Ferreira Ana
Laboratory Of Immunology Department Of Parasitology Microbiology And Immunology Icb Federal Universi
-
Amarante Giovanni
Department Of Chemistry Ice Federal University Of Juiz De Fora
-
ALMEIDA Mauro
Department of Chemistry, ICE, Federal University of Juiz de Fora
-
TEIXEIRA Francisco
Laboratory of Immunology, Department of Parasitology, Microbiology and Immunology, ICB, Federal Univ
-
SOUZA Marcus
Department of Chemistry, ICE, Federal University of Juiz de Fora
-
ALVES Caio
Laboratory of Immunology, Department of Parasitology, Microbiology and Immunology, ICB, Federal Univ
-
CARDOSO Silvia
Department of Chemistry, ICE, Federal University of Juiz de Fora
-
TEIXEIRA Henrique
Laboratory of Immunology, Department of Parasitology, Microbiology and Immunology, ICB, Federal Univ
-
Alves Caio
Laboratory Of Immunology Department Of Parasitology Microbiology And Immunology Icb Federal Universi
-
Souza Marcus
Department Of Chemistry Ice Federal University Of Juiz De Fora
-
Almeida Mauro
Department Of Chemistry Ice Federal University Of Juiz De Fora
-
Cardoso Silvia
Department Of Chemistry Ice Federal University Of Juiz De Fora
-
Teixeira Henrique
Laboratory Of Immunology Department Of Parasitology Microbiology And Immunology Icb Federal Universi
-
Teixeira Francisco
Laboratory Of Immunology Department Of Parasitology Microbiology And Immunology Icb Federal Universi
-
De Souza
Departamento De Bioquimica Centro De Ciencias Biologicas (ccb) Universidade Federal De Pernambuco (ufpe)
関連論文
- Gas chromatographic-mass spectrometric method for the determination of the herbicides paraquat and diquat in plasma and urine samples
- Factors of morbidity in hemispherectomies : Surgical technique×pathology
- Detection and Classification of Transient Disturbances in Power Systems
- Effects of Tea from Turnera ulmifolia L. on Mouse Gastric Mucosa Support the Turneraceae as a New Source of Antiulcerogenic Drugs
- Femoral and acetabular revision using impacted nondemineralized freeze-dried bone allografts
- Influence of Thermomechanical Parameters on the Competition between Dynamic Recrystallization and Dynamic Strain Induced Transformation in C-Mn and C-Mn-Nb Steels Deformed by Hot Torsion
- Bilateral extensive cerebral infarction and mesenteric ischemia associated with segmental arterial mediolysis in two young women
- Thalidomide Analogs from Diamines : Synthesis and Evaluation as Inhibitors of TNF-α Production
- Childhood Bullous Pemphigoid : Report of Three Cases
- Predicting Outcome in Acute Low Back Pain Using Different Models of Patient Profiling
- Early Intervention for the Management of Acute Low Back Pain : A Single-Blind Randomized Controlled Trial Biopsychosocial Education, Manual Therapy, and Exercise
- Antinociceptive Effect of Hydroxydihydrocarvone(Pharmacology)
- Effects of hyperbaric oxygen on Leishmania amazonensis promastigotes and amastigotes
- Comparative expression of syndecan-1 and Ki-67 in peripheral and desmoplastic ameloblastomas and ameloblastic carcinoma
- Preparation of shoot apex of Helianthus annuus L. for analysis with scanning electron microscope
- Trans Polyunsaturated Fatty Acid Contents in Brazilian Refined Soybean Oil
- A new process of IgG purification by negative chromatography : Adsorption aspects of human serum proteins onto ω-aminodecyl-agarose
- Purification of human IgG by negative chromatography on ω-aminohexyl-agarose
- Cytomixis in Brassica napus var. oleifera and Brassica campestris var. oleifera (Brassicaceae)
- In vitro effect of quinolinic acid on energy metabolism in brain of young rats
- Genetic polymorphism of MUC7 in individuals with aggressive or chronic periodontitis
- Correlation of c-erbB-2 oncogene and p53 tumor suppressor gene with malignant transformation of hydatidiform mole
- Pathologic complete response with neoadjuvant imatinib for locally advanced pelvic GIST
- Detection of the first lectin with antimicrobial activity present in serum of the Amazonian fish tambaqui Colossoma macropomum
- Increased IgG1, IFN-γ, TNF-α and IL-6 responses to Mycobacterium tuberculosis antigens in patients with Tuberculosis are lower after chemotherapy
- B_1 and B_2 kinin receptor participation in hyperproliferative and inflammatory skin processes in mice
- Design Methodology for Ti:LiNbO3 Waveguides
- A Simple Homemade Carbon Dioxide Delivery System for Endovascular Procedures in the Iliofemoral Arteries
- Tensile bond strength of cast commercially pure titanium dowel and cores cemented with three luting agents