STRUCTURE-ACTIVITY RELATIONSHIP OF CARDIAC STEROIDS HAVING A DOUBLY LINKED SUGAR AND RELATED COMPOUNDS FOR THE INHIBITION OF Na^+, K^+-ADENOSINE TRIPHOSPHATASE
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概要
- 論文の詳細を見る
Forty-three different cardiac steroids having a doubly linked sugar and related compounds were tested for inhibition of Na^+, K^+-adenosine triphosphatase from guinea pig heart, and the structure-activity relationship has been discussed. The doubly linked glycosides showed higher activities than the respective genins. The inhibitory activities of these compounds were also dependent upon the presence of ring C substituents. The bufadienolide rhamnosides exhibited greater than three times the inhibitory activity of the parent genin, while the glucosyl residue exerted no significant activity.
- 公益社団法人日本薬学会の論文
著者
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Shimada Kazutake
Pharmaceutical Institute Tohoku University
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Shimada Kenji
Division Of Cardiovascular Research Laboratories Tsubame Rosai Hospital:department Of Internal Medic
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Ro Jai
Pharmaceutical Institute Tohoku University
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Nambara T
Tohoku Univ. Sendai Jpn
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Nambara T
Graduate School Of Pharmaceutical Sciences Tohoku University
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Nambara Toshio
Pharmaceutical Institute Tohoku University
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Ohishi K
United Graduate School Of Agricultural Sciences Gifu University
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Ohishi Kazuo
Pharmaceutical Research Laboratories Ajinomoto Co. Inc
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ISHII NAOYUKI
Pharmaceutical Institute, Tohoku University
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RO JAISEUP
Pharmaceutical Institute, Tohoku University
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Ishii N
Pharmaceutical Institute Tohoku University
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