STRUCTURE-ACTIVITY RELATIONSHIP OF BUFOTOXINS AND RELATED COMPOUNDS FOR THE INHIBITION OF Na^+, K^+-ADENOSINE TRIPHOSPHATASE
スポンサーリンク
概要
- 論文の詳細を見る
Forty kinds of bufotoxins and related compounds were tested for inhibition of Na^+, K^+-adenosine triphosphatase from guinea pig heart, and the structure-activity relationship has been discussed. The inhibitory activities of bufotoxins were dependent upon the dicarboxylic acid and amino acid components. The compounds having both the arginine and suberic acid moieties showed the higher inhibitory activities. The sulfates and glucuronides of cardiac steroids exhibited much less potency than the parent genins. The mode of inhibition was determined by means of the Dixon and Lineweaver-Burk plots.
- 公益社団法人日本薬学会の論文
著者
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Shimada Kazutake
Pharmaceutical Institute Tohoku University
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Shimada Kenji
Division Of Cardiovascular Research Laboratories Tsubame Rosai Hospital:department Of Internal Medic
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Ro Jai
Pharmaceutical Institute Tohoku University
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Nambara T
Tohoku Univ. Sendai Jpn
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Nambara T
Graduate School Of Pharmaceutical Sciences Tohoku University
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Nambara Toshio
Pharmaceutical Institute Tohoku University
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Ohishi K
United Graduate School Of Agricultural Sciences Gifu University
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Ohishi Kazuo
Pharmaceutical Research Laboratories Ajinomoto Co. Inc
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Fukunaga Hiroko
Pharmaceutical Institute Tohoku University
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